Multifunctional pelletizing and coating machine
The multi-functional pelletizing and coating machine adopts modular design, and different functional modules can be added according to the use requirements to realize the free switching of centrifugal pelletizing, extrusion rounding and cutting and spraying pelletizing.
Category: Project Display
key word: Liquid Particle Processing System

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Multifunctional pelletizing and coating machine
Equipment Description:
The multi-functional pelletizing and coating machine adopts modular design, and different functional modules can be added according to the use requirements to realize the free switching of centrifugal pelletizing, extrusion rounding and cutting and spraying pelletizing. Through the quick conversion of rotating disc and toothed disc, the machine has the functions of mother starting, granulation, coating, extrusion and rounding at the same time. It has two methods of preparing pellets: centrifugal pelletizing and tangential spraying. It can also put the finished pellets into the material tank and spray atomized coating solution for coating. Pellets have good sphericity, uniform size and high drug utilization. They are suitable for slow-release drug granulation, enteric drug granulation, pellet coating and other processes. They are ideal equipment for pellet preparation process exploration and formula research and development.
Pellets have been widely used in the field of pharmacy. As a drug carrier, it can not only be further pressed into tablets, but also be used in empty capsules. It not only improves the stability of drugs, but also can effectively adjust the drug release rate; As a drug delivery system, pellets have therapeutic advantages, such as less gastrointestinal irritation, reducing the risk of sudden drug release, improving drug safety, and good reproducibility of blood drug concentration; Pellets also have the advantages of good fluidity, low brittleness and easy filling.
In terms of preparation production, compared with other pill making methods, extrusion spheronization technology, as an advanced process widely used in the international preparation industry, has the following characteristics:
-The process operation is carried out in a wet state, and the dust is completely eliminated.
-The yield of the product exceeds 99%. The particle size distribution is narrow, and the qualified product rate is more than 90%.
-The pellets have good roundness, good strength and density of more than 0.8g/cm3, which is conducive to the preparation of film release pellets with uniform coating film.
-The drug loading capacity of pellets is large, and the drug loading capacity can be changed in a wide range
-It is easy to mix incompatible active ingredients.
-The loss of enzyme activity in the production process of enzyme preparation is small, which can be as low as less than 10%.
-The single line production capacity can reach up to 200kg / h (production equipment), with high efficiency, low cost and low labor intensity.
-The process has good reproducibility, parameterized process, easy control and scientific management.
In terms of controlled-release preparations and drug utilization, many factors in extrusion spheronization can change the powder properties and drug release behavior of pellets - the measurement index of pellet quality, mainly including: pellet size, roundness, brittleness, density, fluidity, drug dissolution and microstructure of pellet surface Careful investigation can improve the properties of pellets in order to achieve the expected purpose of medication.
Technical features:
1. This innovative machine has the functions of centrifugal pill making, cutting and spraying pill making and extrusion and spheronization pill making, as well as the functions of centrifugal and side spraying coating; Different pill making modules meet the exploration of pill making technology for materials with different physical properties.
2. Innovative use of DC brushless motor driven rounding, extrusion and servo motor driven peristaltic pump head to supply liquid and powder, so as to increase the reliability and service life of the equipment.
3. The unique atomizer adjusting mechanism and deflector can adjust the material movement track and the new atomizer at any position and angle, so that the combination of materials and adhesive atomized particles can reach the best state and improve the qualified rate.
4. Screw type powder feeder is equipped with bridge breaking mixing device to ensure continuous and stable powder feeding; The lifting device can realize embedded feeding and avoid powder overflow.
5. The optimal design of the tooth profile of the cutting gear disc is processed by four-axis machining center and dynamically balanced.
6. The cyclone separator system and drum filter system for gas-solid separation are configured to separate, recover and filter the tail gas.
7. It is equipped with multiple process modules and adopts touch screen + PLC control system, which can adjust speed steplessly.
8. The structure is unique and novel, and the unique appearance arc design makes the appearance smooth and beautiful.
Technical parameters:
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